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Blood and immune system conditions

About

What is covered

This interactive flowchart covers the guidance that NICE has produced on blood and immune system conditions.
For more information about blood and immune system conditions, including evidence from NICE-accredited sources, visit NICE Evidence Search.

Updates

Updates to this interactive flowchart

22 March 2016 Ruxolitinib for treating disease-related splenomegaly or symptoms in adults with myelofibrosis (NICE technology appraisal guidance 386) added to myelodysplastic syndromes and myeloproliferative disorders.
1 March 2016 Spectra Optia for automated red blood cell exchange in patients with sickle cell disease (NICE medical technology guidance 28) added to sickle cell disease.
26 January 2016 Eltrombopag for treating severe aplastic anaemia refractory to immunosuppressive therapy (terminated appraisal) (NICE technology appraisal 382) added to anaemia.
23 July 2015 Ruxolitinib for disease-related splenomegaly or symptoms in adults with myelofibrosis (NICE technology appraisal guidance 289) added to myelodysplastic syndromes and myeloproliferative disorders.
27 January 2015 Eculizumab for treating atypical haemolytic uraemic syndrome (NICE highly specialised technology guidance 1) added to atypical haemolytic uraemic syndrome.

Your responsibility

Guidelines

The recommendations in this interactive flowchart represent the view of NICE, arrived at after careful consideration of the evidence available. When exercising their judgement, professionals are expected to take these recommendations fully into account, alongside the individual needs, preferences and values of their patients or service users. The application of the recommendations in this interactive flowchart is not mandatory and does not override the responsibility of healthcare professionals to make decisions appropriate to the circumstances of the individual patient, in consultation with the patient and/or their carer or guardian.
Local commissioners and/or providers have a responsibility to enable the interactive flowchart to be applied when individual health professionals and their patients or service users wish to use it. They should do so in the context of local and national priorities for funding and developing services, and in light of their duties to have due regard to the need to eliminate unlawful discrimination, to advance equality of opportunity and to reduce health inequalities. Nothing in this interactive flowchart should be interpreted in a way that would be inconsistent with compliance with those duties.
Commissioners and providers have a responsibility to promote an environmentally sustainable health and care system and should assess and reduce the environmental impact of implementing NICE recommendations wherever possible.

Technology appraisals

The recommendations in this interactive flowchart represent the view of NICE, arrived at after careful consideration of the evidence available. When exercising their judgement, health professionals are expected to take these recommendations fully into account, alongside the individual needs, preferences and values of their patients. The application of the recommendations in this interactive flowchart is at the discretion of health professionals and their individual patients and do not override the responsibility of healthcare professionals to make decisions appropriate to the circumstances of the individual patient, in consultation with the patient and/or their carer or guardian.
Commissioners and/or providers have a responsibility to provide the funding required to enable the recommendations to be applied when individual health professionals and their patients wish to use it, in accordance with the NHS Constitution. They should do so in light of their duties to have due regard to the need to eliminate unlawful discrimination, to advance equality of opportunity and to reduce health inequalities.
Commissioners and providers have a responsibility to promote an environmentally sustainable health and care system and should assess and reduce the environmental impact of implementing NICE recommendations wherever possible.

Medical technologies guidance, diagnostics guidance and interventional procedures guidance

The recommendations in this interactive flowchart represent the view of NICE, arrived at after careful consideration of the evidence available. When exercising their judgement, healthcare professionals are expected to take these recommendations fully into account. However, the interactive flowchart does not override the individual responsibility of healthcare professionals to make decisions appropriate to the circumstances of the individual patient, in consultation with the patient and/or guardian or carer.
Commissioners and/or providers have a responsibility to implement the recommendations, in their local context, in light of their duties to have due regard to the need to eliminate unlawful discrimination, advance equality of opportunity, and foster good relations. Nothing in this interactive flowchart should be interpreted in a way that would be inconsistent with compliance with those duties.
Commissioners and providers have a responsibility to promote an environmentally sustainable health and care system and should assess and reduce the environmental impact of implementing NICE recommendations wherever possible.

Person-centred care

People have the right to be involved in discussions and make informed decisions about their care, as described in your care.
Making decisions using NICE guidelines explains how we use words to show the strength (or certainty) of our recommendations, and has information about prescribing medicines (including off label use), professional guidelines, standards and laws (including on consent and mental capacity), and safeguarding.

Short Text

Everything NICE has said on blood and immune system conditions in an interactive flowchart

What is covered

This interactive flowchart covers the guidance that NICE has produced on blood and immune system conditions.
For more information about blood and immune system conditions, including evidence from NICE-accredited sources, visit NICE Evidence Search.

Updates

Updates to this interactive flowchart

22 March 2016 Ruxolitinib for treating disease-related splenomegaly or symptoms in adults with myelofibrosis (NICE technology appraisal guidance 386) added to myelodysplastic syndromes and myeloproliferative disorders.
1 March 2016 Spectra Optia for automated red blood cell exchange in patients with sickle cell disease (NICE medical technology guidance 28) added to sickle cell disease.
26 January 2016 Eltrombopag for treating severe aplastic anaemia refractory to immunosuppressive therapy (terminated appraisal) (NICE technology appraisal 382) added to anaemia.
23 July 2015 Ruxolitinib for disease-related splenomegaly or symptoms in adults with myelofibrosis (NICE technology appraisal guidance 289) added to myelodysplastic syndromes and myeloproliferative disorders.
27 January 2015 Eculizumab for treating atypical haemolytic uraemic syndrome (NICE highly specialised technology guidance 1) added to atypical haemolytic uraemic syndrome.

Sources

NICE guidance and other sources used to create this interactive flowchart.
Eculizumab for treating atypical haemolytic uraemic syndrome (2015) NICE highly specialised technologies guidance 1
Refractory extrapulmonary sarcoidosis: infliximab (2017) NICE evidence summary ES4
Pulmonary sarcoidosis: infliximab (2016) NICE evidence summary ES2
Autoimmune haemolytic anaemia: rituximab (2015) NICE evidence summary ESUOM39
Immune (idiopathic) thrombocytopenic purpura: rituximab (2014) NICE evidence summary ESUOM35
Active B12 assay for diagnosing vitamin B12 deficiency (2015) NICE medtech innovation briefing 40

Quality standards

Quality statements

Effective interventions library

Effective interventions library

Successful effective interventions library details

Implementation

Information for the public

NICE produces information for the public that summarises, in plain English, the recommendations that NICE makes to healthcare and other professionals.
NICE has written information for the public explaining its guidance on each of the following topics.

Pathway information

Your responsibility

Guidelines

The recommendations in this interactive flowchart represent the view of NICE, arrived at after careful consideration of the evidence available. When exercising their judgement, professionals are expected to take these recommendations fully into account, alongside the individual needs, preferences and values of their patients or service users. The application of the recommendations in this interactive flowchart is not mandatory and does not override the responsibility of healthcare professionals to make decisions appropriate to the circumstances of the individual patient, in consultation with the patient and/or their carer or guardian.
Local commissioners and/or providers have a responsibility to enable the interactive flowchart to be applied when individual health professionals and their patients or service users wish to use it. They should do so in the context of local and national priorities for funding and developing services, and in light of their duties to have due regard to the need to eliminate unlawful discrimination, to advance equality of opportunity and to reduce health inequalities. Nothing in this interactive flowchart should be interpreted in a way that would be inconsistent with compliance with those duties.
Commissioners and providers have a responsibility to promote an environmentally sustainable health and care system and should assess and reduce the environmental impact of implementing NICE recommendations wherever possible.

Technology appraisals

The recommendations in this interactive flowchart represent the view of NICE, arrived at after careful consideration of the evidence available. When exercising their judgement, health professionals are expected to take these recommendations fully into account, alongside the individual needs, preferences and values of their patients. The application of the recommendations in this interactive flowchart is at the discretion of health professionals and their individual patients and do not override the responsibility of healthcare professionals to make decisions appropriate to the circumstances of the individual patient, in consultation with the patient and/or their carer or guardian.
Commissioners and/or providers have a responsibility to provide the funding required to enable the recommendations to be applied when individual health professionals and their patients wish to use it, in accordance with the NHS Constitution. They should do so in light of their duties to have due regard to the need to eliminate unlawful discrimination, to advance equality of opportunity and to reduce health inequalities.
Commissioners and providers have a responsibility to promote an environmentally sustainable health and care system and should assess and reduce the environmental impact of implementing NICE recommendations wherever possible.

Medical technologies guidance, diagnostics guidance and interventional procedures guidance

The recommendations in this interactive flowchart represent the view of NICE, arrived at after careful consideration of the evidence available. When exercising their judgement, healthcare professionals are expected to take these recommendations fully into account. However, the interactive flowchart does not override the individual responsibility of healthcare professionals to make decisions appropriate to the circumstances of the individual patient, in consultation with the patient and/or guardian or carer.
Commissioners and/or providers have a responsibility to implement the recommendations, in their local context, in light of their duties to have due regard to the need to eliminate unlawful discrimination, advance equality of opportunity, and foster good relations. Nothing in this interactive flowchart should be interpreted in a way that would be inconsistent with compliance with those duties.
Commissioners and providers have a responsibility to promote an environmentally sustainable health and care system and should assess and reduce the environmental impact of implementing NICE recommendations wherever possible.

Person-centred care

People have the right to be involved in discussions and make informed decisions about their care, as described in your care.
Making decisions using NICE guidelines explains how we use words to show the strength (or certainty) of our recommendations, and has information about prescribing medicines (including off label use), professional guidelines, standards and laws (including on consent and mental capacity), and safeguarding.

Supporting information

Glossary

Paths in this pathway

Pathway created: November 2014 Last updated: April 2017

© NICE 2017

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